Islet cell tumours
نویسنده
چکیده
Islet cells tumours are a range of rare neoplasms of neuroendocrine origin arising in or close to the pancreas. The normal islet cells of Langerhans in the pancreas contain B-cells (which secrete insulin), A-cells (which secrete glucagon), D-cells (which secrete somatostatin), Dl-cells (which secrete pancreatic polypeptide, PP) and D2-cells (which secrete vasoactive intestinal peptide). The majority (85%) of islet cell tumours secrete one or more of these hormones, or other substances not normally found in the adult pancreas (although often present in the fetal pancreas), notably gastrin.
منابع مشابه
Imaging Islet Cell Tumours
Islet cell tumours are rare lesions. The majority (85%) are functioning hormone-producing tumours, insulinomas and gastrinomas being the most common. Approximately 15% of islet cell tumours are nonfunctioning. These are usually larger lesions, often presenting at an advanced stage as a pancreatic mass or with metastatic disease. This review will focus on the role of endoscopic ultrasound in the...
متن کاملCo-Transplantation of VEGF-Expressing Human Embryonic Stem Cell Derived Mesenchymal Stem Cells to Enhance Islet Revascularization in Diabetic Nude Mice
Background: Pancreatic islet transplantation has emerged as a promising treatment for type I diabetes. However, its efficacy is severely hampered due to poor islet engraftment and revascularization, which have been resulted to partially loss of transplanted islets. It has been shown that local delivery of vascular endothelial growth factor (VEGF) could accelerate transplanted islet revasculari...
متن کاملEndoscopic ultrasound for localisation of islet cell tumours.
In a prospective study endoscopic ultrasound localisation of pancreatic endocrine tumours was attempted in 21 patients with clinically suspected islet cell tumours. Most patients were referred after the failure of conventional imaging methods. Endoscopic ultrasound correctly identified the site of 12 of 15 insulinomas, one glucagonoma, and a diffuse pancreatic abnormality in a patient with mult...
متن کاملPedunculated islet-cell tumour of the duodenum.
An unusual islet-cell tumour found at necropsy in a patient who had died from a myocardial infarction is described. Of particular interest were the pedunculated nature and large size of the tumour. The clinical features of the case are considered. Four islet-cell tumours in the duodenum have previously been reported and it seems probable that such tumours arise in heterotopic pancreas.
متن کاملFrequent loss of heterozygosity at chromosome 3p14.2-3p21 in human pancreatic islet cell tumours.
OBJECTIVE Pancreatic islet betacell tumours occur either sporadically or as part of inherited neoplastic syndromes, most commonly multiple endocrine neoplasia (MEN) type 1. Recently, a transgenic mouse model has been established in which the expression of the SV40 large T antigen was targeted to betacells by the rat insulin promoter, leading to the development of multiple pancreatic betacell tu...
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ورودعنوان ژورنال:
- Cancer Imaging
دوره 4 شماره
صفحات -
تاریخ انتشار 2003